DKTK School of Oncology Tech Talk
„Multiplexed Ion Beam Imaging (MIBI) and its applications in cancer research“
with Dr. Felix Hartmann (DKTK Young Investigator Group)
Wednesday 22.03.23 | 17:00 - 18:00 via Zoom
Join our first School of Oncology Tech Talk in 2023 with Dr. Felix Hartmann who will talk about „Multiplexed Ion Beam Imaging (MIBI) and its applications in cancer research“. After his presentation there will be the opportunity to ask questions to the speaker and to engage in a discussion.
Multiplexed ion beam imaging (MIBI) is a novel technology that enables high-dimensional proteomic imaging of standard tissue sections. In MIBI, antibodies conjugated to metal isotopes are quantified via time-of-flight mass spectrometry to visualize the spatial distribution of up to 40 proteins in parallel. MIBI technology provides a unique combination of advantages: analysis of the spatial distribution of cells in tissues to identify tissue structure, multicellular communities, and cellular interactions; quantification of proteins and posttranslational modifications; adjustable resolution down to sub-cellular level; no autofluorescence background; the dynamic range spans five orders of magnitude; tissue staining imaging of all targets is performed in a single step, and compatibility with a wide range of samples, including fixed-frozen and formalin-fixed paraffin-embedded (FFPE) tissue. Together, these features allow robust, sub-cellular imaging of cellular metabolism and phenotype in large sample collections and human clinical cohorts.
Speaker
Dr. Felix Hartmann (DKTK Young Investigator Group - Systems Immunology and Single Cell Biology)
Dr. Hartmann received a B.Sc. and M.Sc. in Molecular Biotechnology from the University of Heidelberg, Germany, and his Ph.D. from the University of Zurich, Switzerland for his research on T cell effector functions in human autoimmune diseases. In 2017, he joined Stanford University as a postdoctoral fellow to study anti-tumor immunity and its metabolic regulation. Since 2021, Dr. Hartmann heads an independent DKTK Young Investigator Group at the DKFZ in Heidelberg. His research combines single-cell and imaging proteomic technologies with novel biological assays to reveal interactions of immune cells with their local environment and how these interactions impact clinical outcomes in human cancer. Most recently, he has developed a novel approach that enables analysis of cellular metabolism in individual cells and with spatial resolution.
VENUE
The Talk will take place online via Zoom.
Registered participants will receive the login information.
ORGANIZER
DKTK School of Oncology
