Welcome to the International Journal of Cancer Symposium on Principles of Chromatin Remodeling in Cancer and Translational Perspectives
Tight regulation of the spatial and temporal organization of chromatin topology is essential for normal development and a driver of cancer when dysregulated. Epigenetic modifications, including histone modifications, DNA methylation and nucleosome positioning, are essential in orchestrating the temporal regulation of gene expression mediated by the 3-dimensional chromatin conformation. In cancer, single nucleotide mutations and large structural variations affect epigenetic regulation, leading to changes in gene expression networks and altered signaling pathways that drive or promote tumorigenesis. In recent decades, (epi)genetic alterations involving cis-regulatory elements have been recognized as major players in tumorigenesis. This symposium will provide an up-to-date overview of the importance of chromatin topology and regulatory element alterations in cancer and discuss how this information can be relevant for cancer therapy.
We are looking forward to your registration !
The Organizing Committee
CHAIRS
Christoph Plass, Editor-in-Cheif, International Journal of Cancer. German Cancer Research Center, Heidelberg, Germany
Hinrich Gronemeyer, IGBMC, Strasbourg-Illkirch, France
Ruud Delwel, Erasmus MS Cancer Institute, Rotterdam, Netherlands
VENUE
The Symposium will take place in on-site at the:
Lecture Hall, DKFZ Communication Center, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg.
Organizer:
Hosts:
Christoph Plass, Heidelberg, Germany
Hinrich Gronemeyer, Strasbourg-Illkirch, France
Ruud Delwel, Rotterdam, Netherlands
In cooperation with:
