Speaker
Mohammad Abukhalaf
(Deutsches Krebsforschungszentrum)
Description
Identifying major histocompatibility complex (MHC)-bound peptides recognized by specific T-cell receptors (TCRs) is key to developing personalized T-cell therapies. We developed an unbiased pipeline combining immunopeptidomics with TCR functional assays in pancreatic ductal adenocarcinoma (PDAC). MHC class I peptides were fractionated by liquid chromatography (LC) and identified via mass spectrometry (MS). Correlating TCR activity with peptide abundance across fractions enabled robust identification of candidate TCR ligands
| Research type | Translational research |
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Primary author
Mohammad Abukhalaf
(Deutsches Krebsforschungszentrum)
Co-authors
Bruno Schönfelder
(Deutsches Krebsforschungszentrum)
Laura Katharina Steffens
(Deutsches Krebsforschungszentrum)
Rienk Offringa
(Deutsches Krebsforschungszentrum)
Stefan Tenzer
(Deutsches Krebsforschungszentrum)
Yannic Chen
(Deutsches Krebsforschungszentrum)
