Breast cancer affects 1 in 7 women, and the risk of death from metastatic (stage 4) disease remains high. In recent years, chemotherapy and mastectomy have improved the overall survival of breast cancer patients and reduced the incidence of breast cancer in at-risk individuals. However, these treatments are non-specific, and do not eliminate the risk of cancer development, patient relapse, or...
Tumors are complex ecosystems shaped by both the identity and spatial organization of diverse cell types. Understanding how these factors evolve during cancer progression may help reveal coordinated multicellular behaviors linked to disease outcome. In this study, we profiled 522 colorectal samples using multiplexed ion beam imaging (MIBI-TOF) and a 42-marker panel capturing cell lineage,...
More than 150 proteins contribute to the formation and regulation of various RNA modifications in humans. These modifications play a crucial role in cell function by influencing RNA splicing, stability, translocation, translation, and ultimately gene expression. To explore the impact of RNA-modifying proteins on cancer cell function, we conducted comprehensive CRISPR-Cas9 dropout screens...
The world is aging, and improving the health of the elderly is crucial. Elderly individuals are particularly susceptible to immune system failure, leading to increased vulnerability to infectious diseases. Immune responses exhibit sex-specific patterns due to a combination of hormonal and genetic factors, including the number of X chromosomes and the expression of genes escaping X-inactivation...
ZBTB7A is a transcription factor critical for hematopoietic lineage commitment, particularly in promoting erythroid differentiation. In acute myeloid leukemia (AML), ZBTB7A mutations are frequently associated with the t(8;21) translocation, which generates the RUNX1::RUNX1T1 fusion and defines a patient subgroup with relatively favorable outcomes. However, relapse remains a significant...
