Pairs of individuals who live together for long periods of time, e.g., spouses, tend to share similar lifestyles, behaviours, and risk events. As environmental exposures can affect the epigenome, it is hypothesised that pairs of long-term cohabiting couples may exhibit greater similarity in their DNA methylation marker patterns.
Using the ESTHER study, a population-representative cohort...
Background and Aims: The prognostic value of body mass index (BMI) in colorectal cancer (CRC) remains debated, partly due to disease-related weight loss. DNA methylation (DNAm)-based biomarkers that reflect long-term adiposity may offer more stable prognostic insights. We aimed to evaluate whether blood-based DNAm-BMI scores are associated with mortality in CRC patients and how they compare to...
Objective:
Cancer-related fatigue is one of the most common burdens of cancer patients. To date, most studies focused on fatigue during or after cancer treatment. However, investigating pretreatment fatigue may identify underlying factors beyond cancer therapy and enable timely fatigue management.
Methods: 232 breast cancer patients and 41 healthy women were recruited via the NCT Heidelberg...
