DKTK School of Oncology Tech Talk
with Prof. Dr. Bettina Weigelin, Tübingen
Monday 23.09.24 | 16:00 - 17:00 via Zoom
Join our second DKTK School of Oncology Tech Talk in 2024 with Prof. Dr. Bettina Weigelin who will talk about “Multiscale microscopy to understand systemic cancer immunotherapy“. After her presentation there will be ample opportunity to ask questions to the speaker and to engage in a lively discussion.
ABSTRACT
DKTK Tech Talk “Multiscale microscopy to understand systemic cancer immunotherapy“
Understanding the immune response to cancer requires monitoring immune cell function at multiple biological levels, from cellular interactions within tissues to systemic activation and trafficking. Intravital microscopy (IVM) allows real-time observation of immune cell effector function within tumors in vivo. Higher harmonic generation (HHG), a label-free multiphoton imaging technique, further provides tissue context and reveals guidance structures that influence immune cell migration and modulate T cell efficacy in the tumor microenvironment. In addition, tissue clearing and light-sheet microscopy (LSM) have emerged as powerful tools to comprehensively analyze the efficacy of immune targeting of metastatic tumor cells in intact organs ex vivo. In combination, multiscale imaging allows the study of immune cell function from the cellular to the tissue and systemic levels. The Tech-Talk will highlight the role of microscopic imaging in understanding immune cell behavior in cancer and the crosstalk between local immunity in tissues and the systemic response.
SPEAKER
Prof. Dr. Bettina Weigelin
Bettina Weigelin is a professor for Preclinical Imaging of the Immune System at the Werner Siemens Imaging Center at the University of Tübingen, Germany. In 2015, she obtained her PhD in Medical Sciences from the Radboud University of Nijmegen, The Netherlands, where she applied intravital multiphoton imaging to study cancer invasion and immune function in solid tumors. With the support of a Rubicon Young Investigator Award (NWO), she spent 3 years as junior faculty (Instructor) at MD Anderson Cancer Center, Houston, USA, where she used intravital microscopy to develop novel strategies for immunotargeting of prostate cancer bone metastasis. Her current research at the Medical Faculty of the University of Tübingen combines dynamic intravital microscopy with whole-organ light-sheet microscopy and macroscopic PET/MR imaging to provide mechanistic insights into cellular therapies at the tissue and whole-body scale to identify strategies for improved cancer immunotherapies.
VENUE
The talk will take place online via Zoom.
Registered participants will receive the login information.
ORGANIZER
DKTK School of Oncology
https://dktk.dkfz.de/en/training/school-oncology/about-program
