Manuel Fernandez-Escabias
(Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain)Ms
Sofia Carrilho-Candeias
(Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain)Dr
Francisco J Amaro-Gahete
(Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain)
INTRODUCTION
Colon cancer is the third most common malignancy worldwide, with more than 1.1 million new cases diagnosed annually. Surgical resection remains the cornerstone of curative treatment, but induces a substantial physiological stress response, often leading to postoperative complications. While multidisciplinary prehabilitation has shown benefits in reducing major complications rate, evidence regarding the combined effect of structure multidisciplinary prehabilitation and rehabilitation program on postoperative outcomes remains limited.
OBJECTIVE
To evaluate the effects of a multidisciplinary prehabilitation and rehabilitation program (PPP) on postoperative complications and clinical prognosis in patients undergoing colon cancer resection.
METHODS
Ninety patients were randomized to either the usual care group (n=46) or the PPP group (n=44). The intervention consisted on a multidisciplinary prehabilitation (4 weeks) and rehabilitation (12 weeks) program including: (i) supervised concurrent exercise training, (ii) dietary behaviour change and (iii) psychological support. Postoperative outcomes were assessed using the comprehensive complication index (CCI), the proportion of patients experiencing complications (%), and the hospital length of stay.
RESULTS
The PPP exhibited significantly lower CCI scores compared with the control group (median [IQR]: 0.00 [0.00 – 12.20] vs 8.70 [0.00 – 20.90]; P = 0.014), a lower incidence of postoperative complications (40.9% vs 71.7%; P = 0.004; OR = 0.273), and a shorter hospital length of stay (median [IQR]: 5 days [4-6] vs 6 days [4-6]; P = 0.029).
CONCLUSION
A multidisciplinary prehabilitation and rehabilitation programs substantially reduces the severity and incidence of postoperative complications and shortens hospital stay in patients undergoing colon cancer resection.
Keywords
Colon cancer, surgery, prehabilitation, multidisciplinary
| Abstract submitters declaration |
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| Conflict of Interest & Ethical Approval |
yes
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Manuel Fernandez-Escabias
(Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain)
Ms
Sofia Carrilho-Candeias
(Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain)
Dr
Benito Miron
(Service of Surgery, Hospital Universitario Clínico San Cecilio, 18016 Granada, Spain.)
Dr
Francisco J Amaro-Gahete
(Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain)
Mr
Rodrigo Fernandez-Escabias
(Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain)
Ms
Andrea Orellana-Jaen
(Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain)
Mr
Alberto Millan-Martin
(Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain)
Mr
Cristian Garcia-Sanchez
(Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain)
Ms
Maria Tomas-Garcia
(Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain)
Dr
Maria Martinez-Carrillo
(Service of Surgery, Hospital Universitario Clínico San Cecilio, 18016 Granada, Spain.)
Dr
Lucas Jurado-Fasoli
(Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain)
Dr
Juan Luis Lopez-Canovas
(Maimónides Biomedical Research Institute of Córdoba, 14004 Córdoba, Spain.)
Dr
Manuel D Gahete
(Maimónides Biomedical Research Institute of Córdoba, 14004 Córdoba, Spain.)
Dr
Almudena Carniero.-Barrera
(Department of Psychology, Universidad Loyola Andalucía, 41007 Seville, Spain.)
Prof.
Teresa Nestares
(Department of Physiology, Faculty of Pharmacy, University of Granada, 18016 Granada, Spain.)
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