Description
Chairs: Helen Rundqvist & Robin Reschke
Metabolic changes have been consistently observed in survivors of cancer. Despite the strong link between exercise and metabolism, the metabolic effects of exercise in survivors remain largely unknown, especially dynamic responses to acute exercise. This study characterized metabolic changes during and after acute exercise and investigated associations with cancer-related fatigue. METHODS:...
Although prior work suggests that exercise reduces the risk of high-grade prostate cancer, the underlying biological mechanisms remain unclear. We aimed to uncover potential mechanisms using transcriptomic approaches following a 12-week aerobic exercise intervention utilizing the transgenic adenocarcinoma of the mouse prostate (TRAMP) model.
Methods: Twelve TRAMP mice, 8-10 weeks of age,...
Exercise is a potent therapy modality to improve quality of life and physical function in cancer patients, with emerging evidence suggesting benefits for cancer outcomes. Given that the efficacy of cancer immunotherapy relies on sustained antitumor immune responses, high-intensity exercise may enhance its efficacy through immune modulation.
The randomized controlled HI AIM trial...
Background: One way to influence the tumor microenvironment (TME) by exercise through myokines is the cancer-muscle cross talk. The cytokine CXCL9 plays a central role in the regulation of tumor growth and cell proliferation, mediated via the CXC chemokine receptor 3 (CXCR3) signaling pathway. We analyzed whether exercise-conditioned serum has an influence on the CXCL9 concentration in breast...
