ISEO – Inaugural Conference July 22nd & 23rd 2026 - organized by DKFZ

Session

Oral Session 7

Jul 23, 2026, 3:15 PM

Heidelberg Congress Center

Description

Chairs: Helen Rundqvist & Robin Reschke

275. Associations between dynamic metabolic responses to acute exercise and fatigue in survivors of cancer

Ryan Marker (University of Colorado)

7/23/26, 3:15 PM

3 - Talk

Metabolic changes have been consistently observed in survivors of cancer. Despite the strong link between exercise and metabolism, the metabolic effects of exercise in survivors remain largely unknown, especially dynamic responses to acute exercise. This study characterized metabolic changes during and after acute exercise and investigated associations with cancer-related fatigue. METHODS:...

83. Exercise suppresses prostate tumor aggressiveness by altering intratumoral lipid metabolism

Darpan Patel (University of Texas Medical Branch at Galveston)

7/23/26, 3:30 PM

3 - Talk

Although prior work suggests that exercise reduces the risk of high-grade prostate cancer, the underlying biological mechanisms remain unclear. We aimed to uncover potential mechanisms using transcriptomic approaches following a 12-week aerobic exercise intervention utilizing the transgenic adenocarcinoma of the mouse prostate (TRAMP) model.

Methods: Twelve TRAMP mice, 8-10 weeks of age,...

97. A randomized controlled trial testing the immunological impact of high-intensity interval training for patients with metastatic lung cancer in combination with immunotherapy

Gitte Holmen Olofsson (National Center for Cancer Immune Therapy (CCIT-DK))

7/23/26, 3:45 PM

3 - Talk

Exercise is a potent therapy modality to improve quality of life and physical function in cancer patients, with emerging evidence suggesting benefits for cancer outcomes. Given that the efficacy of cancer immunotherapy relies on sustained antitumor immune responses, high-intensity exercise may enhance its efficacy through immune modulation.

The randomized controlled HI AIM trial...

204. Does exercise have an effect on Breast Cancer Cell Growth?

Dorothea Clauss (German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg (a Partnership Between DKFZ and University Medical Center Heidelberg), Heidelberg, Germany)

7/23/26, 4:00 PM

3 - Talk

Background: One way to influence the tumor microenvironment (TME) by exercise through myokines is the cancer-muscle cross talk. The cytokine CXCL9 plays a central role in the regulation of tumor growth and cell proliferation, mediated via the CXC chemokine receptor 3 (CXCR3) signaling pathway. We analyzed whether exercise-conditioned serum has an influence on the CXCL9 concentration in breast...

261. Mitochondrial dysfunction: a key player in doxorubicin-induced skeletal and cardiac muscle damage?

Anouk Hiensch

7/23/26, 4:15 PM

3 - Talk

Introduction
Anthracyclines are effective treatments for solid and hematological cancers but can cause long-lasting toxicities, including skeletal muscle loss (20–70%) and cardiomyopathy (5–48%). These toxicities contribute to fatigue, reduced physical fitness, and poorer quality of life (QoL), and may limit the use of optimal chemotherapy doses, decreasing the chance of survival....