Description
Chairs: Karen Wonders & Elias Dreismickenbecker
INTRODUCTION: Exercise elicits a robust leukocytosis, elevating key effector lymphocytes within the circulation. Following exercise, lymphocytes rapidly egress the circulation, and animal models indicate this egress may increase tumor trafficking and infiltration. We sought to define associations between lymphocytes and exercise intensity during cardiopulmonary exercise testing.
METHODS:...
Background: Habitual physical activity (PA) is associated with preserved physical function in older adults, but underlying biological mechanisms remain unclear. We examined whether skeletal muscle mitochondrial energetics mediated associations of PA with concurrent and future physical function and if pathways differed by cancer survivorship status.
Methods: Participants were 879 adults aged...
Abstract
Background:
Cancer-related cognitive impairment (CRCI) is common among women with breast cancer, yet no pharmacologic prevention exists. Exercise may improve cognition after treatment but less is known about how physical activity (PA) during chemotherapy relates to cognitive outcomes.
Methods:
This secondary analysis included women with breast cancer undergoing chemotherapy...
Purpose:
It is known that a greater physical activity (PA) reduces the risk of breast cancer (BC). Nevertheless, there is still limited evidence about what role PA may play in the prognosis of the disease. The aim of this study was to assess the association of pre- and postdiagnosis PA with overall and BC-specific mortality among BC survivors.
Methods:
A total of 13,399 BC survivors from...
Purpose: Breast cancer (BC) is the most common malignancy worldwide. Neoadjuvant chemotherapy (NACT) has become a standard treatment approach, and achieving pathologic complete response (pCR) is strongly associated with favorable long-term clinical outcomes. Although considerable efforts have focused on identifying tumor-specific predictors of treatment response, the role of host-related...
With the publication of the CHALLENGE Trial, in addition to the publication of multiple exercise guidelines from ACS, ACSM, ASCO, ESSA, and other international organizations, the question becomes: how do we broadly implement exercise for all people living with and beyond cancer. In this abstract we focus on the efforts of a large U.S. based health care system (UPMC) to implement exercise...
