Abstract
Background: Endocrine therapy remains a cornerstone in hormone receptor-positive breast cancer treatment and lasts many years. Although highly effective, these treatments often cause musculoskeletal symptoms such as joint pain, stiffness, carpal tunnel syndrome, tenosynovitis, myalgia, and muscle weakness, severely compromising quality of life. We designed an AI-driven...
Purpose:
It is known that a greater physical activity (PA) reduces the risk of breast cancer (BC). Nevertheless, there is still limited evidence about what role PA may play in the prognosis of the disease. The aim of this study was to assess the association of pre- and postdiagnosis PA with overall and BC-specific mortality among BC survivors.
Methods:
A total of 13,399 BC survivors from...
Background: Supervised exercise mitigates the adverse physical and biological effects of neoadjuvant chemotherapy (NAC) in breast cancer, but implementation in the Chilean public health system is constrained by travel costs, caregiver burden, and treatment fatigue, demanding scalable autonomous alternatives. Aurora is a 9-week home-based, woman-centered design intervention, developed with and...
Background
Breast cancer survivors following mastectomy commonly experience persistent physical and psychological impairments, including fatigue, pain, reduced endurance, and functional limitations. Although exercise oncology interventions are increasingly recommended in survivorship care, evidence from real-world community-based rehabilitation settings remains limited. This study evaluated...
Background:
Each year, approximately 39,000 women with a diagnosis of breast cancer participate in oncological rehabilitation in Germany. Within rehabilitation settings of the German Pension Insurance (Deutsche Rentenversicherung, DRV), exercise therapy represents the largest component in terms of both time and structure among all therapeutic interventions. According to the mandatory DRV...
Background: Postoperative shoulder dysfunction and discomfort are common after mastectomy with immediate breast reconstruction and may delay functional recovery and reduce quality of life. This study evaluated the effects of an early structured exercise program on shoulder functional recovery, discomfort, and safety in women undergoing mastectomy with immediate reconstruction.
Methods: Sixty...
Background and Objective:
Advances in systemic therapies have improved survival in breast cancer, but many patients experience fatigue, reduced physical performance, and impaired quality of life. Increasing evidence supports exercise and rehabilitation as supportive interventions associated with improved function, reduced fatigue, and better survival outcomes. Since 2023, Luzerner...
Community-based approaches offer a scalable model to deliver exercise programming to cancer survivors; however, public health impact depends on reaching a large, representative population. Hybrid effectiveness-implementation (HEI) trials provide an opportunity to assess reach during program evaluation, as effectiveness-focused eligibility criteria and recruitment may constrain reach. This...
Background: Aromatase inhibitor-associated arthralgia (AIA) affects approximately 50% of breast cancer survivors, significantly impairing quality of life (QoL) and treatment adherence. While physical exercise shows promise as a non-pharmacological intervention, optimal prescription parameters remain undefined, particularly in premenopausal women undergoing aromatase inhibitor (AI) therapy with...
Background: Perioperative exercise reduces treatment-related impairments in women with breast cancer, yet access to supervised programs remains limited, particularly in Latin American healthcare systems. Digital platforms offer a scalable alternative, provided they are designed to sustain engagement under the physical and emotional demands of cancer treatment. Oncoactivate was developed...
Background
Shoulder co-morbidities are common after breast cancer treatment, with recent studies showing a high prevalence of subacromial impingement (SI). However, the functional implications of SI remain uninvestigated.
Methods
We examined 13 breast cancer survivors with SI (SI+ group; age 57.8 ± 7.3 years, height 161.6 ± 7.2 cm, body mass 78.6 ± 12.6 kg) eleven breast cancer survivors...
Purpose
The multinational PREFERABLE-EFFECT study showed beneficial effects of a 9-month supervised exercise program on fatigue and quality of life in patients with metastatic breast cancer (mBC).
Here, we investigate exercise effects on objectively and subjectively assessed physical activity (PA) and on physical fitness outcomes.
Methods
In the PREFERABLE-EFFECT study, 357 patients were...
