Cerebellar development and disease at single-cell resolution

Scientific Program

Planned program and time schedule

Day 1. Wed, Sept 11

12.00-14.00 h arrival / check-in / snacks

Welcome and Session 1: Normal cerebellar development
14.00-14.15 h Welcome: Simone Mayer/Lena Kutscher
14.15-15.00 h Mary Beth Hatten, The Rockefeller University, USA: Molecular Control of Cerebellar Circuit Formation
15.00-15.45 h Alex Joyner, Memorial Sloan Kettering Cancer Center, USA: Functional implications of spatially defined molecular subclasses of cerebellar excitatory neurons

15.45-16.15 h Coffee break

16.15-17.00 h Sumru Bayin, University of Cambridge; Gurdon Institute, UK: Unraveling mechanisms of cerebellum development and regeneration
17.00-17.20 h Talk chosen from abstracts
17.20-17.30 h Poster flash talks

17.30-19.00 h Poster session

Day 2. Thur, Sept 12

Session 2: Transcriptional control of cerebellar development

09.00-09.45 h Kathy Millen, Seattle Children’s Hospital, USA: A human-centric view of cerebellar development is required to understand human cerebellar disease
09.45-10.30 h Mari Sepp, University of Heidelberg, DE: Cellular Development of the Mammalian Cerebellum through an Evolutionary Lens

10.30-11.00 h Coffee break

11.00-11:45 h James Li, University of Connecticut, USA: Single cell and spatial expression profiling to decipher the parcellation of the cerebellar cortex

11.45-13.15 h Lunch

13.15-14.00 h Myron Evans, Seattle Children’s Hospital, USA: Epigenetic regulation of cerebellar development and tumorigenesis
14.00-14.20 h Talk chosen from abstracts
14.20-14.30 h Poster flash talks

14.30-16.00 h Poster session

16.15-17.30 h City tour

Day 3. Fri, Sept 13

Session 3: Models of cerebellar development and disease

09.00-09.45 h Giorgia Quadrato, University of Southern California, USA: Modeling human cerebellar development and disease at single cell resolution with organoids
09.45-10.30 h Simone Mayer, Karlsruhe Institute of Technology, DE: Cerebellar organoids as a model for pontocerebellar hypoplasia

10.30-11.00 h Coffee break

11.00-11.45 h Vincent Cantagrel, Institut Imagine, FR: Modeling human cerebellar development and malformations using cerebellar organoids
11.45-12.00 h Talk chosen from abstracts
12.00-12.15 h Talk chosen from abstracts

12.15-13.15 h Lunch

13.15-14.00 h Esther Becker, University of Oxford, UK: Modelling cerebellar diseases using iPSC-derived organoid models
14.00-14.45 h Teresa Silva, University College London, UK: Investigating trisomy 21-associated cerebellar developmental alterations using human cerebellar organoids

14.45-15.15 h Coffee break

15.15-16.00 h Lena Kutscher, German Cancer Research Center, DE: Neurodevelopmental principles underlying pediatric brain cancer
16.00-16.45 h Roy Sillitoe, Baylor College of Medicine, USA: Synaptic origins of cerebellar disease

16.45-17.15 h Break

17.15-18.30 h Final discussion

19.30 h Conference dinner for all participants, Kulturbrauerei Heidelberg