Ms
Catalina Bonet
(Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO). L'Hospitalet de Llobregat, Barcelona, Spain. Programa de doctorat Medicina i Recerca Translacional, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain. Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain.)Dr
Marta Crous-Bou
(Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO). L'Hospitalet de Llobregat, Barcelona, Spain.Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain.)
Background: Evidence shows that obesity and physical inactivity increase breast cancer (BC) risk among postmenopausal women and may also influence prognosis. Evidence from well-designed clinical trials remain insufficient. This study helps fill this gap by evaluating an intervention combining diet and exercise.
Objectives: The primary aim is to assess the effect of the intervention on cancer recurrence in BC survivors. Secondary objectives include evaluating changes in weight and body composition.
Design: A multicentre randomized controlled trial was conducted in seven hospitals. Eligible participants were women aged 18-75 years with non-metastatic BC who have completed standard treatment. Participants were randomly assigned to intervention or control group. The control group received usual care, while the intervention group participated in a 1-year lifestyle program including a calorie reduction diet and moderate-intensity exercise sessions.
Outcomes: The primary outcome for this analysis was weight control at one year, defined as achieving >5% weight loss for women with BMI>25 or maintaining normal weight for women with BMI<25. Secondary outcomes included weight change, BMI and fat mass%.
Results: Of 699 women initially enrolled, 644 were included: 321 assigned to the intervention group and 323 to the control group. At baseline, the mean age of participants was 53.3(sd9.1), 51.3% were postmenopausal and mean BMI was 27(sd4.8). Weight control was achieved by 60.2% of patients in the intervention group versus 45.5% in the control group (p<0.0001). Among women with BMI>25, 70.5% in the intervention group and 43.1% in the control group lost weight. At 12 months, the intervention group had significant lower weight, BMI and fat mass% than the control group. Mean weight loss in the intervention group was 2.2%(95%CI:1.5,2.9), while the control group gained 0.8%(0.0,1.6).
Discussion: In this clinical trial, a combined diet and physical activity intervention induced significant weight control, weight loss and reduction in fat mass.
Keywords
Diet, physical activity, trial, breast cancer prognosis
| Abstract submitters declaration |
yes
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| Conflict of Interest & Ethical Approval |
yes
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Ms
Catalina Bonet
(Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO). L'Hospitalet de Llobregat, Barcelona, Spain. Programa de doctorat Medicina i Recerca Translacional, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain. Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain.)
Dr
Sonia Pernas
(Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain.Medical Oncology Department, Catalan Institute of Oncology (ICO) – Hospital Universitari de Bellvitge. L'Hospitalet de Llobregat, Barcelona, Spain.)
Dr
Beatriz Cirauqui
(Medical Oncology Department, Institut Català d’Oncologia (ICO) – Hospital Universitari Germans Trias i Pujol. Badalona, Spain.B-ARGO group, Germans Trias i Pujol Research Institute (IGTP). Badalona, Spain.)
Dr
Sonia del Barco
(Medical Oncology Department, Institut Català d’Oncologia (ICO) - Hospital Universitari de Girona Doctor Josep Trueta. Girona, Spain. Department of Medical Sciences, Faculty of Medicine. University of Girona, Girona, Spain.)
Dr
Montserrat Muñoz
(Medical Oncology Department, Institut del Càncer i Malalties de la Sang (ICAMS). Hospital Clínic de Barcelona, Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain.)
Dr
Meritxell Mollà
(Radiation Oncology Department, Hospital Clínic de Barcelona, Barcelona, Spain.)
Dr
Esther Zamora
(Medical Oncology Department, Vall d'Hebron University Hospital - Vall d'Hebron Institute of Oncology (VHIO). Barcelona, Spain.)
Dr
Antonio Agudo
(Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO). L'Hospitalet de Llobregat, Barcelona, Spain.Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain.)
Dr
Marta Crous-Bou
(Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO). L'Hospitalet de Llobregat, Barcelona, Spain.Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain.)
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