Christina Yfanti
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Approximately 50-75% of the patients with colorectal cancer and liver metastases (mCRC) who undergo surgery with curative intent, experience disease recurrence within two years1. Repeated rounds of surgery and chemotherapy result in severe physical deconditioning. Exercise has been shown to improve disease-free survival in colorectal cancer, and early post-operative aerobic exercise is associated with fewer adverse events, earlier initiation of chemotherapy, and increases in cardiorespiratory fitness and physical function. However, the effects of a combined aerobic and resistance exercise program, applied in a dose-response manner during the early postoperative period and throughout adjuvant chemotherapy in mCRC patients remains unknown.
This randomized controlled trial investigates the effects of supervised exercise training on peak oxygen consumption (VO₂peak), skeletal muscle strength and function, and quality of life in patients with mCRC.Fifty-seven mCRC patients were randomized 1:1:1 to either 150 or 300 min/week of supervised exercise, or standard care. The intervention consisted of 24 weeks of supervised combined aerobic and resistance training, initiated two weeks following hospital discharge after surgical treatment of liver metastases.
VO₂peak was the primary outcome. Secondary outcomes included skeletal muscle strength, physical function, and quality of life. Assessments were conducted preoperatively and at 12 and 24 weeks after initiation of the exercise intervention. The final participant completed the 24-week follow-up assessment in December 2025, and data analyses are currently ongoing. Results will be available for presentation at the ISEO Conference in July 2025.
Keywords
colorectal liver metastases, supervised exercise training, peak oxygen consumption, liver surgery
| Abstract submitters declaration |
yes
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| Conflict of Interest & Ethical Approval |
yes
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Christina Yfanti
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Dr
Simon N Thomsen
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Dr
Rikke Krabek
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Dr
Lucas A Knøfler
(Department of Digestive Diseases, Transplantation and General Surgery, Centre for Cancer and Organ Diseases, Rigshospitalet, Denmark)
Mrs
Stine Sjoberg
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Mrs
Line NE Rasmussen
(Sjællands Universitetshospital, Næstved, Klinisk Onkologisk Afdeling og Palliative enheder Dansk Forskningscenter for Lighed i Kræft (COMPAS), Denmark)
Mr
Ilias C Barsakis
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Ms
Ioanna C Beriatou
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Mr
Fragkoulis A Karamaounas
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Mr
Nikolas Antoniou
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Mr
Konstantinos Kazantzidis
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Ms
Stella Stylou
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Ms
Anastasia Kaisi
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Mr
Konstantinos Zarogiannis
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Prof.
Morten Mau-Sørensen
(Department of Oncology, Rigshospitalet, Denmark)
Prof.
Peter N Larsen
(Department of Digestive Diseases, Transplantation and General Surgery, Centre for Cancer and Organ Diseases, Rigshospitalet, Denmark)
Prof.
Martin H Sillesen
(Department of Surgical Gastroenterology and Transplantation, Rigshospitalet, Denmark)
Prof.
Nicolai A Schultz
(Department of Digestive Diseases, Transplantation and General Surgery, Centre for Cancer and Organ Diseases, Rigshospitalet, Denmark)
Prof.
Hans-Christian Pommergaard
(Department of Digestive Diseases, Transplantation and General Surgery, Centre for Cancer and Organ Diseases, Rigshospitalet, Denmark)
Prof.
Bente Klarlund Pedersen
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
Dr
Casper Simonsen
(Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen)
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