Introduction: In lung cancer, physical activity may help to manage treatment-related side effect thus improving treatment tolerance. However, a cancer diagnosis often triggers behavioral shifts that may contribute to increase the sedentary habits and reduce physical activity. This study esplored physical activity levels, nutritional and sarcopenia risk, and cardiorespiratory fitness (CRF) in...
Background
Colorectal cancer (CRC) incidence is rising among adults under 55 years, but its causes remain unclear. Large-scale prospective studies are needed to identify risk factors for early-onset CRC (EOCRC).
Methods
We pooled three large European prospective cohort studies, examining 14 known or suspected risk factors with EOCRC (diagnosed <55 years, N = 1369) and later-onset CRCs...
Background
Baseline physical function may predict the toxicity of chimeric antigen receptor (CAR) T-cell therapy. The MD Anderson Cancer Center (MDACC) prehabilitation program evaluates older adults prior to CAR T-cell therapy to assess baseline physical function and optimize physical activity.
Objective
To evaluate the association of baseline physical function with the risk of CAR T-cell...
Background
Robotic-assisted colorectal cancer (CRC) surgery is increasingly adopted due to improved surgical precision and recovery profiles, yet postoperative complications remain common. Cardiopulmonary exercise testing (CPET) provides objective measures of physiological reserve, but it is unclear which CPET-derived parameters are most clinically informative for risk stratification in...
Background: Exercise is increasingly integrated into supportive care for lung cancer, but objective evidence for patients with advanced disease remains limited. We synthesized randomized trials to quantify the effects of exercise on cardiorespiratory fitness and muscle strength in advanced lung cancer.
Methods: PubMed, the Cochrane Library, Web of Science, and CINAHL were searched up to June...
Chimeric antigen receptor T-cell therapy (CART), used to treat hematologic malignancies, including multiple myeloma (MM) and diffuse large cell B lymphoma (DLBCL), offers a chance of lasting remission for relapsed and refractory disease. Unfortunately, symptom burden can be high and impact clinical outcomes and functionality, leading to impaired patient quality of life. PURPOSE: Assess...
Background: Postoperative bowel dysfunction—including increased bloating, fecal incontinence, and embarrassment—is highly prevalent among colorectal cancer survivors and substantially impairs quality of life. Although exercise has shown promise for improving bowel motility, pelvic floor function, and overall physical recovery, little is known about which types of exercise are effective...
INTRODUCTION:Patients with lung cancer often experience treatment-related physical deterioration, including reduced cardiorespiratory capacity, muscle strength, and functional performance, as well as unfavorable changes in body composition, negatively affecting quality of life.
OBJECTIVE:To analyze the effects of a supervised exercise program implemented in a community setting for patients...
Background: Patients with gastric cancer experience progressive muscle loss after surgery. Postoperative sarcopenia has been associated with increased mortality and complications; however, the effects of exercise on body composition after gastrectomy remain unclear.
Objective: To evaluate the effects of an early postoperative exercise program on CT-measured skeletal muscle area in patients...
ABSTRACT
Background: Higher levels of physical activity (PA) are associated with better quality of life in survivors of head and neck cancer (sHNC). Nevertheless, many sHNC exhibit sedentary behaviour or engage in very low activity levels. Particularly those with advanced disease are challenged by the sequelae of their extensive treatment regimens. Switzerland lacks guidelines on...
Background
Aging is associated with progressive declines in muscle strength and mobility, which may be exacerbated in individuals with cancer due to disease-related systemic inflammation, metabolic dysregulation, and accelerated muscle catabolism. In colorectal cancer, tumor-driven cytokine activity, decreased nutritional intake, and reduced habitual physical activity may further compromise...
Backgrounds
Physical activity is an established protective factor for several cancers, but whether its association with lung cancer differs by histological subtype and sex remains unclear. Clarifying these differences is essential for precision prevention.
Objective
To examine associations between physical activity and lung cancer risk across major histological...
Objective:
Preclinical models using osteogenic exercise have demonstrated mechanical load-induced changes delay osteolytic activity and rescue bone loss. Our recent work in multiple myeloma (MM) identified individualised targeted exercise can reduce bone pain; however, research is yet to explore the potential effect of exercise on bone health. The MyeEx-Impact multi-site randomised...
INTRODUCTION
Patients with pancreatic cancer often experience fatigue, sarcopenia, and reduced physical function, which can impair daily activities and quality of life. Targeted physical activity interventions, including both aerobic and resistance exercises, are essential to maintain muscle mass, improve functional capacity, and support treatment outcomes. The EU-Project RELEVIUM integrates...
Background:
Early detection of glioblastoma (GBM) recurrence remains challenging. In clinical practice, distiguishing true tumor progression from treatment-related changes such as radiation necrosis (pseudoprogression) is difficult. Therefore, complementary markers of early disease activity are of interest. Based on own experiences, we investigated systematically whether documented changes in...
Approximately 50-75% of the patients with colorectal cancer and liver metastases (mCRC) who undergo surgery with curative intent, experience disease recurrence within two years1. Repeated rounds of surgery and chemotherapy result in severe physical deconditioning. Exercise has been shown to improve disease-free survival in colorectal cancer, and early post-operative aerobic exercise is...
Background: Exercise programs benefit lung cancer patients undergoing surgery but are rarely incorporated into clinical practice. Predictors of adherence to a perioperative remotely delivered, pragmatic, and personalized exercise intervention in lung cancer patients were assessed.
Methods: Patients randomized to the exercise group in the Precision Exercise Prescription (PEP) Study were...
Introduction
Exercise-induced benefits in cancer patients have been consistently observed in exercise oncology research but precise manipulation of training variables (e.g., volume, intensity, frequency) is key to optimize clinically relevant patient-reported outcomes among breast cancer survivors (BCS). Evidence indicates that resistance training (RT) is safe, feasible, ameliorates...
Background: Patients with non-small cell lung cancer (NSCLC) receiving immunotherapy typically present low levels of physical activity and high sedentary behavior, negatively affecting health outcomes and quality of life. Conventional exercise programs often show poor long-term adherence, highlighting the need for community-based and patient-centered models that align with individual...
Colorectal cancer (CRC) and its treatment are frequently associated with autonomic nervous system (ANS) dysregulation, characterized by alterations in heart rate variability (HRV) and insufficient levels of physical activity (PA). This cross-sectional, single-center observational study (Phase 1) evaluated patients with Stage III–IV CRC from the Abdominal Surgery Service of Erasto Gaertner...
Background: Hospitalization for hematopoietic stem cell transplantation (HSCT) is associated with inactivity, and deconditioning in children, adolescent and young adults (CAYAs). Interventions promoting mobility during HSCT are limited. TEAM Me (Totally Excited About Moving, Mobility and Exercise) is a program utilizing a token economy system to encourage physical activity during...
BACKGROUND
Lung cancer is the leading cause of cancer death in the UK. Patients are often older, frail, and nutritionally compromised, and routinely excluded from research. Activity and nutrition interventions improve quality of life (QoL) and may enhance treatment outcomes, yet evidence in this population remains limited. The CanBenefit programme addresses this gap through a programme of...
Background
Exercise prehabilitation can mitigate the risks of cancer surgery, however low recruitment and adherence are commonly described in trials. Patients with low baseline physical activity (PA) levels are likely to benefit the most from prehabilitation but have the lowest uptake. The person-based approach (PBA) is a set of methods for developing effective complex behavioural...
BACKGROUND: Patients with advanced thoracic cancers undergoing standard radiotherapy (RT) have a high risk of experiencing performance declines and poor quality of life (QOL). Exercise programs may improve objective and subjective performance; yet adherence remains poor. Including family caregivers as active intervention participants may improve adherence and thus efficacy. Thus, this clinical...
