Description
Chairs: Sandi Hayes & Andreas Schneeweiß
Rationale: Preclinical and observational evidence suggests that exercise may enhance primary tumor treatment, but evidence from clinical trials is scarce. We therefore conducted a randomized controlled trial to examine the effects of adding exercise to neoadjuvant chemotherapy (NACT) on clinical outcomes.
Methods: In the BENEFIT trial, breast cancer patients scheduled for NACT were...
Background: Impaired sleep quality is a common burden in patients with breast cancer, yet the effects of exercise on sleep quality, particularly in patients with metastatic disease (mBC), remain understudied. Therefore, the effects of supervised exercise on sleep quality in patients with mBC were investigated in the multinational randomized controlled PREFERABLE-EFFECT...
Background:
Immune function critically influences chemotherapy efficacy. Preclinical evidence is that exercise mobilizes NK and CD8+ T cells, enhances immunosurveillance, and improves treatment response. However, its immunological effects during chemotherapy for breast cancer remain poorly defined.
Methods:
This non-randomized pilot study examined a 12-week supervised combined aerobic-...
Background: Exercise during chemotherapy for breast cancer (BCa) offers significant health benefits and could influence disease progression. Evidence suggests that exercise-induced circulating factors mediate such anticarcinogenic effects, although the implicated cellular processes remain uncharacterized.
Method: Twenty-nine BCa patients (40.0±0.9 yrs, 25.0±0.8 kg/m2) were randomized with...
PURPOSE: Insulin resistance (IR) and hyperglycemia are common side effects of cancer therapy, and IR that persists despite treatment cessation is likely much more common than previously estimated. It is unclear if habitual physical activity (PA) alters cancer-induced IR in the year after diagnosis. METHODS: Fasting glucose, insulin, and self-reported PA were measured at diagnosis, 6-, and...
