Background: A sedentary lifestyle increases prostate cancer (PCa) risk and contributes to cardiometabolic disease. Nordic Walking (NW) is a simple, accessible form of physical activity that may improve population health. We investigated adherence-dependent longitudinal effects of supervised NW on clinical, functional, and cardiometabolic outcomes in sedentary men undergoing PCa...
Background
Most exercise interventions for men with prostate cancer utilise resistance and aerobic exercise, though the optimal combination of each for cardiometabolic health and quality of life (QOL) outcomes is unclear.
Objective
The objective of this study was to compare an aerobic-emphasised (AE) with a resistance-emphasised (RE) exercise intervention in men with prostate...
Background
Colon cancer is the fifth most common type of cancer worldwide. Its diagnosis and treatment impose substantial physical and psychological stress, frequently leading to anxiety and depression rates that exceed those observed in the general population. These conditions negatively affect postoperative outcomes and quality of life, with effects that may persist during and after...
Background: Evidence from observational studies and clinical trials suggests that exercise may reduce anxiety and depressive symptoms. However, data are limited among people with metastatic disease, who have poorer prognoses and higher mental health burden.
Methods: The INTERVAL-GAP4 study is a phase III 2-year randomized controlled trial testing the effect of high-intensity resistance and...
Introduction: The potential for long-term exercise to affect the metabolome in healthy individuals is well established. Given the metabolic underpinnings of prostate cancer, it is important to investigate whether long-term exercise similarly alters the metabolome in disease-affected men. This study is among the first to characterize metabolic changes in individuals with prostate cancer,...
Background
Global prostate cancer cases are projected to double to 2.9 million annually by 2040. While androgen deprivation therapy (ADT) is a cornerstone of treatment, it induces rapid and severe adverse effects, including loss of lean mass and increased fat mass. Intervening during the initial phase of ADT is critical, yet a significant evidence gap persists regarding effective, scalable...
Objective: This study investigated the effectiveness of exercise prehabilitation on functional capacity, health-related quality of life (HRQoL), and body composition in head and neck cancer (HNC) patients initially proposed for definitive chemoradiotherapy (CRT).
Methods: In this randomized controlled trial (NCT05418842), patients were allocated to an exercise prehabilitation program...
Background: Perioperative treatment is the standard of care for resectable gastroesophageal cancer; however, physical deterioration during neoadjuvant treatment is common and may ultimately preclude tumor surgery. Here, we compared exercise training with control on the likelihood of not undergoing tumor surgery following neoadjuvant treatment.
Methods: In this parallel-group,...
Exercise attenuates many treatment-related declines, with a growing interest in the direct impact on prostate cancer (PC) cell viability. While supervised exercise decreases PC cell growth, it is unknown if home-based exercise or serum from men with advanced PC have similar impacts. PURPOSE: To assess the effects of home-based exercise training on LNCaP and PC-3 viability in men with...
Introduction
Prostate cancer is the most diagnosed cancer for men in NZ. It’s treatment often involves androgen deprivation therapy (ADT) and radiation therapy (RT) which can cause some debilitating side effects which can greatly impact patients physical functioning and quality of life for years post treatment completion.
Exercise has consistently been seen to significantly help alleviate...
Introduction
Prehabilitation is increasingly recognised as a critical component of cancer surgery pathways. However, data outlining the degree of postoperative functional decline despite prehabilitation is not well documented in this patient group.
This pilot study aimed to assess postoperative functional decline in a surgical cohort who received prehabilitation, and evaluate the...
Background
Low physical performance is associated with increased postoperative morbidity, mortality, and cardiopulmonary complications. Physical activity can reduce therapy-related side effects and have a positive impact on disease progression. Despite guideline recommendations of 150 minutes of moderate activity per week, many patients fail to meet these targets.
...
Background
Black Prostate Cancer survivors (PCa) undergoing androgen deprivation therapy (ADT) are at higher risk of body composition alterations, such as sarcopenia, which translate to poorer overall survival when compared to non-black PCa. Although the prognostic relevance of sarcopenia has been established, this outcome is understudied among Black PCa on ADT. Therefore, the aim of this...
Background: Androgen deprivation therapy (ADT) is a key treatment for advanced and metastatic prostate cancer (PCa), but is frequently associated with fatigue, metabolic alterations, depressive symptoms, and reduced quality of life. National and international guidelines recommend physical activity to counteract these adverse effects. Previous intervention studies have mainly focused on...
Background: Prehabilitation aims to improve patients’ resilience to surgery and enhance postoperative recovery. Understanding rationales for prehabilitation content may identify opportunities for program optimization. This systematic review provides an overview of rationales, intervention, and outcomes used in prehabilitation studies in oncological populations.
Methods: We searched...
Introduction: Active Together is a prehabilitation and rehabilitation service in South Yorkshire UK providing multi-modal support to people receiving curative cancer treatment. Integrated into local cancer pathways, the service provides exercise, dietetic and psychological support, delivered by clinicians and exercise professionals and tailored to each patient's individual needs. Since its...
Purpose
Complex and demanding neoadjuvant treatment regimens lead to reduced performance in patients with Non-Small Cell Lung Cancer (NSCLC), which can increase perioperative morbidity and prolong postoperative recovery. Combining multimodal prehabilitation with chemo- and immunotherapy may provide an opportunity to rapidly initiate cancer-directed therapy while improving functional status in...
PurposeIn prehabilitation, patients who often have little experience with exercise are challenged to achieve high levels of exercise adherence in a short timeframe. To translate RCT findings into standard care and understand factors influencing feasibility and efficacy, detailed reporting of exercise adherence is important. This may also help tailor exercise to individual patient needs. We...
