Lisa Schwab
(Institute of Sport Science, Dpt. Sports Medicine, Disease Prevention & Rehabilitation, Johannes Gutenberg University Mainz)
INTRODUCTION
Patients with pancreatic cancer often experience fatigue, sarcopenia, and reduced physical function, which can impair daily activities and quality of life. Targeted physical activity interventions, including both aerobic and resistance exercises, are essential to maintain muscle mass, improve functional capacity, and support treatment outcomes. The EU-Project RELEVIUM integrates personalized app-based training recommendations into standard care to improve multimodal supportive care for patients with pancreatic cancer.
METHODS
RELEVIUM is a multicenter randomized clinical trial (n = 132) incorporating an 8-week intervention and 16-week follow-up. At study entry, patients undergo standardized physical assessments (6-Minute Walk Test (6MWT), 5 Times sit to stand Test (FTSST), Handgrip-strength test (HGST), Brief-BESTest), which serve as the basis for tailoring an exercise program according to the ACSM guidelines. Training takes place unsupervised at home and is adjusted weekly based on patient-reported feedback and data captured by digital monitoring tools, including smartwatch-collected information on physical activity, heart rate, exercise type, duration, and perceived exertion. Daily fatigue ratings collected through the mobile app further guide session modifications. Exercise recommendations (aerobic and strength) are adapted as needed by an exercise therapist, and engaging an activity partner is intended to support adherence.
RESULTS
At this stage, only baseline data from the clinical center in Mainz are available. To date, 9 patients (90% male) with a mean age of 64 ± 4.6 years have been enrolled. Baseline characteristics are shown as mean ± standard deviation: 6MWT: 431.8 ± 68.4 m; FTSST: 11.8 ± 2.7 s; HGST dominant arm: 39.7 ±11.5 kg; Brief-BESTest Score: 20.6 ±3.6.
DISCUSSION
The study is still ongoing and aims to provide information on whether an individually tailored telemedicine approach is accepted and adopted by this patient group.
Keywords
Digital Health, Telemedicine, Pancreatic Cancer, Physical Activity
| Abstract submitters declaration |
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| Conflict of Interest & Ethical Approval |
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Lisa Schwab
(Institute of Sport Science, Dpt. Sports Medicine, Disease Prevention & Rehabilitation, Johannes Gutenberg University Mainz)
Kira Enders
(Institute of Sport Science, Dpt. Sports Medicine, Disease Prevention & Rehabilitation, Johannes Gutenberg University Mainz)
Gabrielle Oestreicher
(Department of Medicine 1, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany)
Barlo Hillen
(Institute of Sport Science, Dpt. Sports Medicine, Disease Prevention & Rehabilitation, Johannes Gutenberg University Mainz, Mainz, Germany; Institute of Occupational, Social and Environmental Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany)
Anneli Elme
(Põhja-Eesti Regionaalhaigla, North Estonia Medical Centre, Tallinn, Estonia)
Tal Goshenlago
(Fishman Oncology Center, Rappaport Faculty of Medicine, Rambam Health Care Campus, Haifa, Israel)
Christos Diou
(Department of Informatics and Telematics, Harokopio University of Athens, Athens, Greece)
Aristotelis Ballas
(Department of Informatics and Telematics, Harokopio University of Athens, Athens, Greece)
Aggeliki Vlachostergiou
(EXUS AI Labs, Athens, Greece)
Lorenzo Giuliani
(EXUS AI Labs, Athens, Greece)
Alexander Scherer
(Fraunhofer Institute for Industrial Mathematics, Kaiserslautern, Germany)
Maximilian Pilz
(Fraunhofer Institute for Industrial Mathematics, Kaiserslautern, Germany)
Murray Heymann
(Fraunhofer Institute for Industrial Mathematics, Kaiserslautern, Germany)
Lazaros Apostolidis
(Centre for Research & Technology Hellas, Thessaloniki, Greece)
Isa Wasswa Musisi
(MCS Datalabs, Berlin, Germany)
Hristina Doncheva
(ROSENBAUM CONSULTING Ltd, Sofia, Bulgaria)
Eva Ester Molina Beltran
(Saint-Cloud, University Versailles Saint-Quentin, France and Ambroise Paré University Hospital, Institute Curie, Boulogne-Billancourt, France)
Markus Moehler
(Department of Medicine 1, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany)
Perikles Simon
(Institute of Sport Science, Dpt. Sports Medicine, Disease Prevention & Rehabilitation, Johannes Gutenberg University Mainz, Mainz, Germany)
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