Introduction: Breast cancer-related lymphoedema (BCRL) is a prevalent condition associated with lifelong physical, psychological and social burden, and lower quality of life. The primary aim of this trial is to determine if adding exercise therapy or compression therapy to usual care can prevent BCRL. Secondary aims evaluate effects on patient-reported outcomes and the cost-effectiveness of...
Introduction. Observational evidence links exercise to longer survival, but to date, no causality has been demonstrated. The primary aim of the STARLighT trial is to evaluate the impact of a structured exercise and nutrition intervention on pathological complete response (pCR) in patients undergoing neoadjuvant treatment and on disease-free survival (DFS) in patients undergoing adjuvant...
Background
Patients with incurable gastroesophageal adenocarcinoma (GAC) experience an impaired health-related quality of life (HRQoL), which might further deteriorate over time. These patients are often confronted with significant life-impacting symptoms, such as fatigue and reduced physical functioning. Exercise combined with nutritional support may improve these outcomes. However,...
Background: Persistent fatigue is a complex and highly distressing late effect after cancer, reported by more than one-third of women treated for breast cancer (BC). Randomized controlled trials (RCTs) investigating the effect of multidisciplinary interventions among cancer survivors with persistent fatigue are lacking. In a recently completed RCT in fatigued lymphoma survivors (the...
Background Exercise has been suggested as a promising non-pharmaceutical intervention for cancer treatment induced peripheral neuropathy (CIPN). However, current evidence is limited to only a few, mostly small, studies with heterogeneous interventions and methodological limitations, and only a limited number of studies focus on chronic CIPN. In addition, data on the cost-effectiveness of...
Background and Purpose: Moderate to vigorous intensity physical activity (MVPA; i.e., aerobic and resistance exercise) improves physical function and quality of life for cancer survivors and is associated with reductions in cancer-specific and all-cause mortality. Unfortunately, recent estimates suggest that only 14% of individuals with a cancer history are engaging in the amount of MVPA...
Older adults, who represent nearly half of new cancer diagnoses in France, remain largely underrepresented in phase I trials (<7%). Functional decline and frailty are key barriers to their participation. The primary purpose of the ENERGY study is to determine whether a multimodal intervention combining exercise, nutritional management, and psychological support can improve inclusion and...
Background:
Since introduction of immune checkpoint inhibitors, the prognosis of melanoma has improved markedly in both adjuvant and metastatic settings. More recently, neoadjuvant therapy has emerged as an alternative to adjuvant treatment and has shown encouraging clinical and pathological outcomes for patients with melanoma, although long-term survival data are still maturing. Exercise...
Background
Despite strong evidence supporting exercise in cancer care, uptake into routine practice remains low. Exercise during chemotherapy infusion (intra-infusion) offers a novel strategy to address this gap. Exercise could enhance treatment efficacy by acutely increasing tumour blood flow, potentially enhancing drug delivery when performed simultaneously with chemotherapy infusion....
Introduction
Research in exercise oncology has consistently provided evidence supporting the integration of exercise into all phases of cancer care but less is known about how this can be implemented across patient groups, geographical borders and health care systems. This study, part of the Interreg South Baltic Program-funded project “AMBeR” (Advanced Modelling of Baltic E-cancer caRe),...
Background. Chemotherapy side effects often cause dose reductions or delays in women with breast cancer (BC), and relative dose intensities below 85% are linked to poorer prognosis and reduced treatment efficacy. Exercise may modulate treatment response by influencing the tumor microenvironment. Recent evidence suggests that exercise may contribute to tumor regression during neoadjuvant...
The CCTG CO.21 Trial is a large randomized controlled trial that recently improved disease-free survival and overall survival in colon cancer patients after a 3-year structured exercise program. PURPOSE: This sub-study leverages data from the CO.21 Trial to test the effect of the first 12-months of physical activity behaviour change intervention (EG) compared to health-education group (HEG) on...
Purpose: Improving the effectiveness of breast cancer (BC) treatment remains a major priority due to its high incidence and mortality. Neoadjuvant chemotherapy (NACT) is widely used in triple negative and HER2 positive disease, and in selected luminal HER2 negative cases. Evidence suggests that structured exercise may enhance treatment responses. This RCT aims to: (1) determine whether adding...
Background: Our research shows that symptoms of lower-extremity lymphedema are commonly reported in women who have undergone surgery for endometrial cancer. Although previous trials have demonstrated beneficial effects of exercise training on lymphedema among women with breast cancer, the feasibility and efficacy to treat lower-extremity lymphedema in women with gynecological cancer remains...
Background
Exercise is vital in prostate cancer survivorship, yet many men face barriers to traditional programmes, particularly gym-based options that may not align with their preferences. The Danish FC Prostate Cancer initiative, a recreational football model, has shown strong feasibility and acceptability by offering a culturally familiar, male-friendly alternative that supports social...
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of neurotoxic cancer treatments, primarily affecting sensory and motor functions in hands and feet. CIPN can interfere with daily activities and cancer treatment. Exercise may represent a promising approach to CIPN prevention; however, it is not currently reflected in international guidelines because evidence...
Background: Lifestyle factors such as physical activity (PA) may help prevent and reduce adverse effects of androgen deprivation therapy (ADT) in men with prostate cancer. Most evidence on PA in this population comes from exercise-based interventions or self-reported measures that primarily capture structured exercise. While exercise can be beneficial, it is not always appealing or feasible...
In the UK, supervised exercise is recommended by NICE for prostate cancer patients receiving androgen deprivation therapy (ADT); however, engagement in physical activity remains limited. Although high adherence is observed during supervised exercise, it is unclear whether participants maintain activity after supervision. Barriers include treatment-related side-effects and low motivation....
Background: Metastatic colorectal cancer is largely incurable. The primary goal of first-line treatment is to prolong survival while maintaining acceptable levels of health-related quality of life. However, chemotherapy is associated with substantial treatment-related toxicity, and 30–50% of patients with mCRC experience clinically relevant reductions in health-related quality of life during...
Introduction: Cancer-related fatigue (CRF) disproportionally impacts survivors of adolescent and young adult (YA) brain tumors. CRF is understudied and poorly managed in this population. While exercise training has demonstrated efficacy at improving CRF in adult cancer survivors—potentially by improving cellular energy production and reducing inflammation— it has not been tested in fatigued YA...
